Atrial fibrillation remains a significant unmet medical need. Current therapeutic and interventional options are inadequate and the incidence of AF is projected to grow significantly over the coming years. It is currently treated either through pharmacological intervention with a combination of rhythm control, rate control and anticoagulation therapies; electrical cardioversion; and/or catheter ablation. PAF results in high direct and indirect costs including physician visits, ER visits and extended hospital stays, in addition to costs related to complications as a result of invasive procedures.