A novel approach to deliver flecainide to the heart: A study in healthy volunteers to compare the cardiovascular effects of inhaled vs intravenous flecainide

Belardinelli | Circulation 2017; 136:A16888

Flecainide (FLEC) is effective for cardioversion of recentonset atrial fibrillation (AF). In dogs and pigs intratracheal instillation of FLEC is effective in terminating episodes of AF within minutes. The present study is part of a drug development program to use inhaled (IH) of FLEC to cardiovert paroxysmal AF. In this open-labeled 2-period crossover study, we compared the effects of FLEC administered via IV and oral IH on QRS, and PR interval duration, heart rate (HR), blood pressure (BP), and FLEC plasma levels.

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